In vivo modeling of metastatic human high-grade serous ovarian cancer in mice.

doi:10.1371/journal.pgen.1008808

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Article

In vivo modeling of metastatic human high-grade serous ovarian cancer in mice.

PLoS genetics - 1 Jun 2020

Kim Olga, Park Eun Young, Klinkebiel David L, Pack Svetlana D, Shin Yong-Hyun, Abdullaev Zied, Emerson Robert E, Coffey Donna M, Kwon Sun Young, Creighton Chad J, Kwon Sanghoon, Chang Edmund C, Chiang Theodore, Yatsenko Alexander N, Chien Jeremy, Cheon Dong-Joo, Yang-Hartwich Yang, Nakshatri Harikrishna, Nephew Kenneth P, Behringer Richard R, Fernández Facundo M, Cho Chi-Heum, Vanderhyden Barbara, Drapkin Ronny, Bast Robert C, Miller Kathy D, Karpf Adam R, Kim Jaeyeon

Abstract excerpt

Metastasis is responsible for 90% of human cancer mortality, yet it remains a challenge to model human cancer metastasis in vivo. Here we describe mouse models of high-grade serous ovarian cancer, also known as high-grade serous carcinoma (HGSC), the most common and deadliest human ovarian cancer type. Mice genetically engineered to harbor Dicer1 and Pten inactivation and mutant p53 robustly replicate the...

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PMID: 32497036
DOI: 10.1371/journal.pgen.1008808
PMCID: PMC7297383

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