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Article

Loss of TNF signaling facilitates the development of a novel Ly-6C(low) macrophage population permissive for Leishmania major infection.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2012

Fromm Phillip D, Kling Jessica, Mack Matthias, Sedgwick Jonathon D, Körner Heinrich

Abstract excerpt

In the absence of TNF, the normally resistant C57BL/6 (B6.WT) strain develops a fatal, progressive form of leishmaniasis after infection with Leishmania major. It is not yet understood which TNF activity or the lack thereof is responsible for the dramatic progression of leishmaniasis in TNF-negative (B6.TNF(-/-)) mice. To elucidate the underlying mechanisms resulting in the fatal outcome of L. major infection in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leishmaniasis, Cutaneous

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Share to Microscopy, Confocal

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Source

Identifiers

PMID: 22615203
DOI: 10.4049/jimmunol.1100977

Genes

TNF
CCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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