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Article

Tumor necrosis factor receptor 2 plays a minor role for mycobacterial immunity.

Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 2000

Jacobs M, Brown N, Allie N, Chetty K, Ryffel B

Abstract excerpt

Tumor necrosis factor (TNF) signalling via the TNF receptor 1 (TNF-R1) is required for host resistance to mycobacterial infection. The role of TNF-R2 in anti-mycobacterial immunity is not known. Therefore, we compared TNF-R1 and TNF-R2 knockout (KO) mice infected with Mycobacterium bovis BCG (10(7) CFU, i.v.). While the bacterial burden of TNF-R1-deficient mice was significantly increased and the mice succumbed...

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Source

Identifiers

PMID: 10878503
DOI: 10.1159/000028116

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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