Article
Phenotypic analysis of TNFR1-deficient mice and characterization of TNFR1-deficient fibroblasts in vitro.
Circulatory shock - 1 Oct 1994
Rothe J, Mackay F, Bluethmann H, Zinkernagel R, Lesslauer W
Abstract excerpt
In order to analyse the physiological relevance of the 55 kDa tumor necrosis factor receptor 1 (TNFR1) and its role in various TNF related pathological conditions, such as septic shock, we have generated mice by gene targeting deficient for TNFR1 expression. The TNFR1-deficient mice are unable to...
Topics
- Alleles
- Animals
- Cells, Cultured
- Fibroblasts
- Flow Cytometry
- Gene Targeting
- Interleukin-1
- Lipopolysaccharides
- Mice
- Phenotype
- Receptors, Tumor Necrosis Factor
- Shock, Septic
- Survival
- Tumor Necrosis Factor-alpha