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Article

Rapidly fatal leishmaniasis in resistant C57BL/6 mice lacking TNF.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2001

Wilhelm P, Ritter U, Labbow S, Donhauser N, Röllinghoff M, Bogdan C, Körner H

Abstract excerpt

The resolution of infections with the protozoan parasite Leishmania major in mice requires a Th1 response that is closely associated with the expression of IL-12, IFN-gamma, and inducible NO synthase. Previous Ab neutralization studies or the use of mice deficient for both TNF receptors suggested...

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Share to Antibodies, Protozoan
Share to Dose-Response Relationship, Immunologic
Share to Hypersensitivity, Delayed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leishmania major

Share to Leishmaniasis, Visceral

Share to Mice, Congenic

Share to Nitric Oxide Synthase Type II

Share to Radiation Chimera

Source

Identifiers

PMID: 11238648
DOI: 10.4049/jimmunol.166.6.4012

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11238648-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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