Article
TACI deficiency leads to alternatively activated macrophage phenotype and susceptibility to Leishmania infection.
Proceedings of the National Academy of Sciences of the United States of America - 28 Jul 2015
Allman Windy R, Dey Ranadhir, Liu Lunhua, Siddiqui Shafiuddin, Coleman Adam S, Bhattacharya Parna, Yano Masahide, Uslu Kadriye, Takeda Kazuyo, Nakhasi Hira L, Akkoyunlu Mustafa
Abstract excerpt
The TNF family member, transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI), is a key molecule for plasma cell maintenance and is required in infections where protection depends on antibody response. Here, we report that compared with WT mouse, TACI KO Μϕs expressed lower levels of Toll-like receptors (TLRs), CD14, myeloid differentiation primary response protein 88, and adaptor...
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