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Article

Fas death receptor signaling represses monocyte numbers and macrophage activation in vivo.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2004

Brown Nathaniel J, Hutcheson Jack, Bickel Emily, Scatizzi John C, Albee Lee D, Haines G Kenneth, Eslick Joy, Bradley Kathleen, Taricone Elsa, Perlman Harris

Abstract excerpt

Over 1 billion monocytes are produced daily, with a small percentage differentiating into macrophages, suggesting that excess monocytes are deleted through a tightly regulated process. Although the in vivo mechanism governing monocyte/macrophage homeostasis is unknown, deletion of monocytes in culture is mediated by the Fas death pathway and is blocked by M-CSF. To determine the in vivo significance of Fas in...

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Source

Identifiers

PMID: 15585886
DOI: 10.4049/jimmunol.173.12.7584

Genes

CCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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