Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Matrix metalloproteinase-12 deficiency attenuates experimental crescentic anti-glomerular basement membrane glomerulonephritis.

Nephrology (Carlton, Vic.) - 1 Feb 2018

Abraham Abu P, Ma Frank Y, Mulley William R, Nikolic-Paterson David J, Tesch Greg H

Abstract excerpt

AIM: Matrix metalloproteinase-12 (MMP-12; macrophage elastase) is an enzyme that can cleave various extracellular matrix proteins and is required for macrophage infiltration and pulmonary fibrosis in experimental emphysema. We have shown previously that MMP-12 is highly up-regulated in experimental anti-glomerular basement membrane (GBM) disease. The aim of this study was to determine whether MMP-12 is required...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemokine CCL2
Share to Inflammation Mediators

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney Glomerulus

Share to Macrophages

Share to Matrix Metalloproteinase 12

Share to Nitric Oxide Synthase Type II

Share to Proteinuria

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 27862656
DOI: 10.1111/nep.12964

Genes

CCL2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Matrix metalloproteinase-12 deficiency attenuates experimental crescentic anti-glomerular basement membrane glomerulonephritis.PMID 27862656Read ↗

Leukocyte-derived MMP9 is crucial for the recruitment of proinflammatory macrophages in experimental glomerulonephritis.Semantic proximity Read ↗

Matrix metalloproteinase 12 overexpression in myeloid lineage cells plays a key role in modulating myelopoiesis, immune suppression, and lung tumorigenesisSemantic proximity Read ↗

Involvement of matrix metalloproteinase-2 in the development of renal interstitial fibrosis in mouse obstructive nephropathy.Semantic proximity Read ↗

Macrophage Migration Inhibitory Factor deficiency attenuates kidney Injury by downregulating cytokines via CYR61 in lupus-prone mice induced by pristane.Semantic proximity Read ↗

Matrix Metalloproteinase-2 Knockout and Heterozygote Mice Are Protected from Hydronephrosis and Kidney Fibrosis after Unilateral Ureteral Obstruction.Semantic proximity Read ↗

T-bet deficiency attenuates renal injury in experimental crescentic glomerulonephritis.Semantic proximity Read ↗

Infiltrating macrophages and interferon gamma rather than renal genotype dictate heightened crescentic glomerulonephritis.Semantic proximity Read ↗

Role of matrix metalloproteinases in kidney development and glomerulopathy: lessons from transgenic mice.Semantic proximity Read ↗

Aberrant macrophages mediate defective kidney repair that triggers nephritis in lupus-susceptible mice.Semantic proximity Read ↗

Alpha-1 Antitrypsin-Deficient Macrophages Have Increased Matriptase-Mediated Proteolytic Activity.Semantic proximity Read ↗

CD206+ mono-macrophages are involved in Antineutrophil Cytoplasmic Antibodies associated glomerulonephritisSemantic proximity Read ↗

Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.