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Article

Leukocyte-derived MMP9 is crucial for the recruitment of proinflammatory macrophages in experimental glomerulonephritis.

Kidney international - 1 May 2013

Kluger Malte A, Zahner Gunther, Paust Hans-Joachim, Schaper Melanie, Magnus Tim, Panzer Ulf, Stahl Rolf A K

Abstract excerpt

Matrix metalloproteinase 9 (MMP9) is a conditionally expressed enzyme and is upregulated in glomerulonephritis. Its function in these diseases, however, remains to be fully elucidated. The induction of nephrotoxic serum nephritis (NTN) in wild-type mice resulted in an upregulation of MMP9, followed by leukocyte infiltration, albuminuria, and subsequent renal failure. MMP9 deficiency ameliorated the course of NTN...

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Identifiers

PMID: 23344471
DOI: 10.1038/ki.2012.483

Genes

MMP9

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