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Article

An intracellular matrix metalloproteinase-2 isoform induces tubular regulated necrosis: implications for acute kidney injury.

American journal of physiology. Renal physiology - 1 Jun 2017

Ceron Carla S, Baligand Celine, Joshi Sunil, Wanga Shaynah, Cowley Patrick M, Walker Joy P, Song Sang Heon, Mahimkar Rajeev, Baker Anthony J, Raffai Robert L, Wang Zhen J, Lovett David H

Abstract excerpt

Acute kidney injury (AKI) causes severe morbidity, mortality, and chronic kidney disease (CKD). Mortality is particularly marked in the elderly and with preexisting CKD. Oxidative stress is a common theme in models of AKI induced by ischemia-reperfusion (I-R) injury. We recently characterized an intracellular isoform of matrix metalloproteinase-2 (MMP-2) induced by oxidative stress-mediated activation of an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28331061
DOI: 10.1152/ajprenal.00461.2016
PMCID: PMC5495883

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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