Article

Artesunate Alleviate Kidney Fibrosis by Restoring Klotho Protein and Suppressing Wnt/β-Catenin Signalling Pathway

2025-03-20

Abstract excerpt

Chronic kidney disease (CKD) is a global health concern that often progresses to renal failure and premature death. Regardless of etiology of CKD, kidney fibrosis is the main determinant of progressive CKD. Renal fibrosis is characterized by excessive collagen and extracellular-matrix (ECM) deposition, which impairs renal function with an irreversible loss of nephrons. Currently, there are no effective antifibroti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 02563a6b-7bef-5aff-b24a-cee355660151
DOI: 10.1101/2025.03.20.644310

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Artesunate Alleviate Kidney Fibrosis by Restoring Klotho Protein and Suppressing Wnt/β-Catenin Signalling PathwayDOI 10.1101/2025.03.20.644310Read

Apamin inhibits renal interstitial inflammation and fibrosis via suppressing TGF-β1 and STAT3 signaling pathway in vivo and in vitroSemantic proximity Read

Bergapten Ameliorates Renal Fibrosis by Inhibiting FerroptosisSemantic proximity Read

Mesenchymal stem cell-derived exosome miR-21-3p prevents renal fibrosisSemantic proximity Read

Quercetin Inhibits Fibroblast Activation and Kidney Fibrosis Involving the Suppression of Mammalian Target of Rapamycin and β-catenin SignalingSemantic proximity Read

The Role of miRNA in Renal Fibrosis Leading to Chronic Kidney DiseaseSemantic proximity Read

Analysis of the potential biological mechanisms of diosmin against renal fibrosis based on network pharmacology and molecular docking approachSemantic proximity Read

AAV-mediated Klotho gene delivery attenuates renal fibrosis in chronic kidney disease by suppressing the TGF-β/Smad3 signaling pathwaySemantic proximity Read

Role of the TGF‑β/Smad signaling pathway in the transition from acute kidney injury to chronic kidney disease (Review)Semantic proximity Read

Inhibition of proliferation-linked signaling cascades with atractylenolide I reduces myofibroblastic phenotype and renal fibrosis.Semantic proximity Read

Epidermal growth factor receptor activation is essential for kidney fibrosis developmentSemantic proximity Read

TGF-β Signaling: a Potential Therapeutic Target of Single Herbs and Extracts for Renal FibrosisSemantic proximity Read

TGF-β Signaling: a Potential Therapeutic Target of Single Herbs and Extracts for Renal FibrosisSemantic proximity Read