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Article

MKK3-p38 signaling promotes apoptosis and the early inflammatory response in the obstructed mouse kidney

9 Aug 2007

Abstract excerpt

Activation of the p38 mitogen-activated protein kinase (MAPK) pathway induces inflammation, apoptosis, and fibrosis. However, little is known of the contribution of the upstream kinases, MMK3 and MKK6, to activation of the p38 kinase in the kidney and consequent renal injury. This study investigated the contribution of MKK3 to p38 MAPK activation and renal injury in the obstructed kidney. Groups of eight...

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PMID: 17686961
DOI: 10.1152/ajprenal.00010.2007

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