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Article

IRF‐1 promotes renal fibrosis by downregulation of Klotho

21 Jan 2020

Abstract excerpt

Although the key role of renal fibrosis in the progression of chronic kidney disease (CKD) is well known, the causes of renal fibrosis are not fully clarified. In this study, interferon regulatory factor 1 (IRF-1), a mammalian transcription factor, was highly expressed in fibrotic kidney of CKD patients. Concordantly, the expression level of IRF-1 was significantly elevated in the kidney of unilateral ureteral...

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PMID: 31965641
DOI: 10.1096/fj.201902446r

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