Genetics of systemic lupus erythematosus: contributions of mouse models in the era of human genome-wide association studies.

Abstract excerpt

The past two years have brought great progress in the genetics of systemic lupus erythematosus (SLE) heralded by the publication of genome-wide association studies in humans and the identification of susceptibility genes in mouse models of spontaneous lupus. This influx of new information has revealed an ever-increasing interdependence between the mouse and human systems for unraveling the genetic basis of lupus...

Topics

• Animals
• Disease Models, Animal
• Genetic Loci
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Humans
• Lupus Erythematosus, Systemic
• Mice