Article
Control of bone resorption in mice by Schnurri-3.
Proceedings of the National Academy of Sciences of the United States of America - 22 May 2012
Wein Marc N, Jones Dallas C, Shim Jae-Hyuck, Aliprantis Antonios O, Sulyanto Rosalyn, Lazarevic Vanja, Poliachik Sandra L, Gross Ted S, Glimcher Laurie H
Abstract excerpt
Mice lacking the large zinc finger protein Schnurri-3 (Shn3) display increased bone mass, in part, attributable to augmented osteoblastic bone formation. Here, we show that in addition to regulating bone formation, Shn3 indirectly controls bone resorption by osteoclasts in vivo. Although Shn3 plays no cell-intrinsic role in osteoclasts, Shn3-deficient animals show decreased serum markers of bone turnover....
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