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Article

Selective Runx2-II deficiency leads to low-turnover osteopenia in adult mice.

Developmental biology - 15 Jul 2005

Xiao Zhousheng, Awad Hani A, Liu Shiguang, Mahlios Josh, Zhang Shiqin, Guilak Farshid, Mayo Matthew S, Quarles Leigh Darryl

Abstract excerpt

Runx2 transcribes Runx2-II and Runx2-I isoforms with distinct N-termini. Deletion of both isoforms results in complete arrest of bone development, whereas selective loss of Runx2-II is sufficient to form a grossly intact skeleton with impaired endochondral bone development. To elucidate the role of Runx2-II in osteoblast function in adult mice, we examined heterozygous Runx2-II (Runx2-II(+/-)) and homozygous...

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Identifiers

PMID: 15936013
DOI: 10.1016/j.ydbio.2005.04.028
PMCID: PMC1360182

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