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Article

Thyrostimulin Regulates Osteoblastic Bone Formation During Early Skeletal Development.

Endocrinology - 1 Sept 2015

Bassett J H Duncan, van der Spek Anne, Logan John G, Gogakos Apostolos, Bagchi-Chakraborty Jayashree, Williams Allan J, Murphy Elaine, van Zeijl Clementine, Down Jenny, Croucher Peter I, Boyde Alan, Boelen Anita, Williams Graham R

Abstract excerpt

The ancestral glycoprotein hormone thyrostimulin is a heterodimer of unique glycoprotein hormone subunit alpha (GPA)2 and glycoprotein hormone subunit beta (GPB)5 subunits with high affinity for the TSH receptor. Transgenic overexpression of GPB5 in mice results in cranial abnormalities, but the role of thyrostimulin in bone remains unknown. We hypothesized that thyrostimulin exerts paracrine actions in bone and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26018249
DOI: 10.1210/en.2014-1943
PMCID: PMC4541616

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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