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Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency

11 May 2007

Abstract excerpt

Runx2 is an essential transcription factor for osteoblast differentiation. However, the functions of Runx2 in postnatal bone development remain to be clarified. Introduction of dominant-negative (dn)-Runx2 did not inhibit Col1a1 and osteocalcin expression in mature osteoblastic cells. In transgenic mice that expressed dn-Runx2 in osteoblasts, the trabecular bone had increased mineralization, increased volume, and...

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PMID: 17497678
DOI: 10.1002/dvdy.21187

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Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiencyPMID 17497678Read ↗

Runx2, a multifunctional transcription factor in skeletal development.Semantic proximity Read ↗

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Runx2 Regulates Endochondral Ossification Through Control of Chondrocyte Proliferation and DifferentiationSemantic proximity Read ↗

Mice lacking the calcineurin inhibitor Rcan2 have an isolated defect of osteoblast function.Semantic proximity Read ↗

Selective deficiency of the "bone-related" Runx2-II unexpectedly preserves osteoblast-mediated skeletogenesis.Semantic proximity Read ↗

Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formationSemantic proximity Read ↗

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Microarray analysis on Runx2-deficient mouse embryos reveals novel Runx2 functions and target genes during intramembranous and endochondral bone formation.Semantic proximity Read ↗

Targeting Runx2 expression in hypertrophic chondrocytes impairs endochondral ossification during early skeletal developmentSemantic proximity Read ↗

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