Article

Increased Osteoclast Activity Contributes to Bone Resorption and Osteopenia in a Rett Syndrome Mouse Model

2026-04-24

Abstract excerpt

<h4>ABSTRACT</h4> Rett syndrome is a severe neurodevelopmental disorder caused predominantly by loss-of-function mutations in the X-linked gene MECP2 . Besides a vast array of neurological and physiological impairments, patients also frequently develop severe osteopenia with increased fracture risk, however, the mechanisms underlying these skeletal defects are not completely understood. Previous work in Mecp2 -...

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Literature Corpus work: bab85c39-171b-58b8-bed1-813b0e9117c1
DOI: 10.64898/2026.04.24.720567

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