Article
Variation in the gene for muscle-specific AMP deaminase is associated with insulin clearance, a highly heritable trait.
Diabetes - 1 Apr 2005
Goodarzi Mark O, Taylor Kent D, Guo Xiuqing, Quiñones Manuel J, Cui Jinrui, Li Xiaohui, Hang Tieu, Yang Huiying, Holmes Edward, Hsueh Willa A, Olefsky Jerrold, Rotter Jerome I
Abstract excerpt
The rising prevalence of the insulin resistance syndrome in our society necessitates a better understanding of the genetic determinants of all aspects of insulin action and metabolism. We evaluated the heritability of insulin sensitivity and the metabolic clearance rate of insulin (MCRI) as quantified by the euglycemic-hyperinsulinemic clamp in 403 Mexican Americans. We tested the candidate gene AMP deaminase 1...
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