Article
Insulin sensitivity and insulin clearance are heritable and have strong genetic correlation in Mexican Americans.
Obesity (Silver Spring, Md.) - 1 Apr 2014
Goodarzi Mark O, Langefeld Carl D, Xiang Anny H, Chen Yii-Der I, Guo Xiuqing, Hanley Anthony J G, Raffel Leslie J, Kandeel Fouad, Nadler Jerry L, Buchanan Thomas A, Norris Jill M, Fingerlin Tasha E, Lorenzo Carlos, Rewers Marian J, Haffner Steven M, Bowden Donald W, Rich Stephen S, Bergman Richard N, Rotter Jerome I, Watanabe Richard M, Wagenknecht Lynne E
Abstract excerpt
OBJECTIVE: The GUARDIAN (Genetics UndeRlying DIAbetes in HispaNics) consortium is described, along with heritability estimates and genetic and environmental correlations of insulin sensitivity and metabolic clearance rate of insulin (MCRI). METHODS: GUARDIAN is comprised of seven cohorts, consisting of 4,336 Mexican-American individuals in 1,346 pedigrees. Insulin sensitivity (SI ), MCRI, and acute insulin...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.