Article
Coincident linkage of fasting plasma insulin and blood pressure to chromosome 7q in hypertensive hispanic families.
Circulation - 11 Sept 2001
Cheng L S, Davis R C, Raffel L J, Xiang A H, Wang N, Quiñones M, Wen P Z, Toscano E, Diaz J, Pressman S, Henderson P C, Azen S P, Hsueh W A, Buchanan T A, Rotter J I
Abstract excerpt
BACKGROUND: Insulin resistance (IR) and hyperinsulinemia are phenotypically associated with hypertension. We have previously provided evidence that blood pressure (BP) and IR cosegregate in Hispanic families, suggesting that this association has a genetic component. In the present study, we provide further support for the hypothesis of a genetic basis for the BP-IR relationship from a genetic linkage study....
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