Article
Linkage of serum insulin concentrations to chromosome 3p in Mexican Americans.
Diabetes - 1 Mar 2000
Mitchell B D, Cole S A, Hsueh W C, Comuzzie A G, Blangero J, MacCluer J W, Hixson J E
Abstract excerpt
Hyperinsulinemia predicts the development of type 2 diabetes, and family studies suggest that insulin levels are regulated in part by genes. We conducted a genome-wide scan to detect genes influencing variation in fasting serum insulin concentrations in 391 nondiabetic individuals from 10 large multigenerational families. Approximately 380 microsatellite markers with an average spacing of 10 cM were genotyped in...
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