Article
Genome-wide scans for heritability of fasting serum insulin and glucose concentrations in hypertensive families.
Diabetologia - 1 Apr 2005
Freedman B I, Rich S S, Sale M M, Heiss G, Djoussé L, Pankow J S, Province M A, Rao D C, Lewis C E, Chen Y D I, Beck S R
Abstract excerpt
AIMS/HYPOTHESIS: The heritability of fasting serum insulin and glucose concentrations in non-diabetic members of multiplex hypertensive families is unknown. METHODS: We calculated the familial aggregation of fasting serum glucose and insulin concentrations and performed a genome-wide scan to assess whether quantitative trait loci contribute to these phenotypes in 2,412 non-diabetic individuals from 1,030 families...
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