Article
Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5.
Circulation research - 22 Jun 2012
Chen Jenny X, Krane Markus, Deutsch Marcus-Andre, Wang Li, Rav-Acha Moshe, Gregoire Serge, Engels Marc C, Rajarajan Kuppusamy, Karra Ravi, Abel E Dale, Wu Joe C, Milan David, Wu Sean M
Abstract excerpt
RATIONALE: Direct reprogramming of fibroblasts into cardiomyocytes is a novel strategy for cardiac regeneration. However, the key determinants involved in this process are unknown. OBJECTIVE: To assess the efficiency of direct fibroblast reprogramming via viral overexpression of GATA4, Mef2c, and Tbx5 (GMT). METHODS AND RESULTS: We induced GMT overexpression in murine tail tip fibroblasts (TTFs) and cardiac...
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