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Article

Chemical Enhancement of In Vitro and In Vivo Direct Cardiac Reprogramming

14 Nov 2016

Abstract excerpt

BACKGROUND: Reprogramming of cardiac fibroblasts into induced cardiomyocyte-like cells in situ represents a promising strategy for cardiac regeneration. A combination of 3 cardiac transcription factors, Gata4, Mef2c, and Tbx5 (GMT), can convert fibroblasts into induced cardiomyocyte-like cells, albeit with low efficiency in vitro. METHODS: We screened 5500 compounds in primary cardiac fibroblasts to identify the...

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PMID: 27834668
DOI: 10.1161/circulationaha.116.024692

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