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Direct reprogramming of fibroblasts into cardiomyocytes

25 May 2017

Abstract excerpt

Cardiovascular diseases are the leading causes of death in the world. The limited regenerative capacity of adult cardiomyocytes is the major barrier for heart regeneration. After myocardial infarction, myofibroblasts are the dominant cell type in the infarct zone. Therefore, it is a good idea to reprogram terminally differentiated myofibroblasts into cardiomyocyte-like cells directly, providing a good strategy to...

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PMID: 28545505
DOI: 10.1186/s13287-017-0569-3

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