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From fibroblast cells to cardiomyocytes: direct lineage reprogramming

14 Jan 2011

Abstract excerpt

Recent advances in stem cell biology have established the feasibility of reprogramming human and murine fibroblast cells into induced pluripotent stem cells. Three master regulators have been demonstrated to be sufficient in the management of cell status of 'pluripotent' versus 'differentiated'. The same strategy has been used to directly convert one somatic cell type into another cell type, such as the...

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PMID: 21241459
DOI: 10.1186/scrt42

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