Article
Heart repair by reprogramming non-myocytes with cardiac transcription factors.
Nature - 13 May 2012
Song Kunhua, Nam Young-Jae, Luo Xiang, Qi Xiaoxia, Tan Wei, Huang Guo N, Acharya Asha, Smith Christopher L, Tallquist Michelle D, Neilson Eric G, Hill Joseph A, Bassel-Duby Rhonda, Olson Eric N
Abstract excerpt
The adult mammalian heart possesses little regenerative potential following injury. Fibrosis due to activation of cardiac fibroblasts impedes cardiac regeneration and contributes to loss of contractile function, pathological remodelling and susceptibility to arrhythmias. Cardiac fibroblasts account for a majority of cells in the heart and represent a potential cellular source for restoration of cardiac function...
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