Article
Polymorphisms of intron 1 and the promoter region at the PRNP gene in BSE-free Caracu cattle.
Biochemical genetics - 1 Oct 2012
Galvão Cleber Eduardo, Rosinha Grácia Maria Soares, Sanches Cristiane Camargo, Elisei Carina, Araújo Flábio Ribeiro, Feijó Gelson Luís Dias, de Almeida Torres Roberto Augusto, Soares Cleber Oliveira
Abstract excerpt
The infectious prion protein PrP(Sc) is encoded by the PRNP gene. In cattle, insertion/deletion (indel) polymorphisms are among the changes that occur in this gene, the most studied of which are within intron 1 (12 bp) and the promoter region (23 bp). Sequence variants in this gene may affect the formation of PrP(Sc). In the present study, nucleotide variability in specific regions of the PRNP gene in Caracu...
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