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Recent progress in assays for GPCR drug discovery

11 Jul 2022

Abstract excerpt

G-protein-coupled receptors (GPCRs), also known as seven transmembrane receptors, are the largest family of cell surface receptors in eukaryotes. There are ∼800 GPCRs in human, regulating diverse physiological processes. The GPCRs are the most intensively studied drug targets. Drugs that target GPCRs account for about a quarter of the global market share of therapeutic drugs. Therefore, to develop physiologically...

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PMID: 35816640
DOI: 10.1152/ajpcell.00464.2021

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