Article

Metastable GPCR dimers trigger the basal signal by recruiting G-proteins

2020-02-11

Abstract excerpt

G-protein-coupled receptors (GPCRs) constitute the largest family of integral membrane proteins in the human genome and are responsible for various important signaling pathways for vision, olfaction, gustation, emotion, cell migration, etc. A distinct feature of the GPCR-family proteins is that many GPCRs, including the prototypical GPCR, β2-adrenergic receptor (β2AR), elicit low levels of basal constitutive signa...

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Literature Corpus work: d6c94336-eed2-536c-844d-0605464e6660
DOI: 10.1101/2020.02.10.929588

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