Article
ID1 expression associates with other molecular markers and is not an independent prognostic factor in cytogenetically normal acute myeloid leukaemia.
British journal of haematology - 1 Jul 2012
Damm Frederik, Wagner Katharina, Görlich Kerstin, Morgan Michael, Thol Felicitas, Yun Haiyang, Delwel Ruud, Valk Peter J M, Löwenberg Bob, Heuser Michael, Ganser Arnold, Krauter Jürgen
Abstract excerpt
In acute myeloid leukaemia with normal karyotype (CN-AML), gene mutations (e.g. NPM1, FLT3, CEBPA) as well as deregulated gene expression affect outcome. High expression of ID1 was described as a negative prognostic factor. We have shown that CEBPA regulates ID1 expression. Therefore, we analysed the prognostic impact of ID1 expression in 269 patients (aged 16-60 years) with CN-AML in the context of other...
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