IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication.

doi:10.1200/JCO.2010.28.3762

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Article

IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Aug 2010

Paschka Peter, Schlenk Richard F, Gaidzik Verena I, Habdank Marianne, Krönke Jan, Bullinger Lars, Späth Daniela, Kayser Sabine, Zucknick Manuela, Götze Katharina, Horst Heinz-A, Germing Ulrich, Döhner Hartmut, Döhner Konstanze

Abstract excerpt

PURPOSE: To analyze the frequency and prognostic impact of isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) mutations in acute myeloid leukemia (AML). PATIENTS AND METHODS: We studied 805 adults (age range, 16 to 60 years) with AML enrolled on German-Austrian AML Study Group (AMLSG) treatment trials AML HD98A and APL HD95 for mutations in exon 4 of IDH1 and IDH2. Patients were also studied...

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Identifiers

PMID: 20567020
DOI: 10.1200/JCO.2010.28.3762

Genes

IDH2
IDH1
NPM1
FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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