CD34 expression predicts an adverse outcome in patients with NPM1-positive acute myeloid leukemia.

doi:10.1016/j.humpath.2013.03.007

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Article

CD34 expression predicts an adverse outcome in patients with NPM1-positive acute myeloid leukemia.

Human pathology - 1 Oct 2013

Dang Harry, Chen Yan, Kamel-Reid Suzanne, Brandwein Joseph, Chang Hong

Abstract excerpt

Patients with acute myeloid leukemia (AML) harboring an NPM1 mutation exhibit a heterogeneous clinical outcome. Recent studies have shown that the absence of FLT3 internal tandem duplication (FLT3-ITD) mutation confers a favorable prognosis in NPM1-positive AML. However, the prognostic impact of immunophenotypes in this subgroup remains unclear. In this study, FLT3 mutation status and immunophenotypic profile of...

Topics

Adult
Age Factors
Aged
Antigens, CD34
Biomarkers, Tumor
Bone Marrow Cells
Canada
DNA Mutational Analysis
Female
Humans
Kaplan-Meier Estimate
Karyotyping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukemia, Myeloid, Acute

Leukocyte Count

Leukocytosis

Male

Middle Aged

Mutation

Source

Open in PubMed

Identifiers

PMID: 23701943
DOI: 10.1016/j.humpath.2013.03.007

Genes

FLT3
NPM1
EFS

Provenance

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