High Id1 expression is associated with poor prognosis in 237 patients with acute myeloid leukemia.

Abstract excerpt

Inhibitors of differentiation (Id) are a group of dominant inhibitors of basic helix-loop-helix transcriptional factors, which promote excessive proliferation, and also protect cells against drug-induced apoptosis in mammalians. Recently, Id1 has been identified as a common downstream target of several constitutively activated oncogenic tyrosine kinase, such as FLT3 internal tandem duplication, in leukemia cells....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to fms-Like Tyrosine Kinase 3
• Share to Leukemia, Myeloid, Acute