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Prognostic relevance of combined IDH1 and NPM1 mutations in the intermediate cytogenetic de novo acute myeloid leukemia.

Cellular and molecular biology (Noisy-le-Grand, France) - 25 Nov 2021

Abd El-Lateef Amal Ezzat, Ismail Manar M, Almohammadi Mohammed, Gawaly Amr M

Abstract excerpt

Despite the great advance in treatment, cytogenetically normal Acute myeloid leukemia (CN-AML) is still a challenging entity. The discovery of IDH1 mutation in AML together with the frequent co-mutations; NPM1 and FLT3-ITD throughs a new insight into the pathogenesis and outcome of CN-AML. Recently, there has been an increasing number of recurring mutations in other genes for which the forecasting effect is still...

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PMID: 34933728
DOI: 10.14715/cmb/2021.67.3.12

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