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Article

Acute myeloid leukemia with biallelic CEBPA gene mutations and normal karyotype represents a distinct genetic entity associated with a favorable clinical outcome.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Feb 2010

Dufour Annika, Schneider Friederike, Metzeler Klaus H, Hoster Eva, Schneider Stephanie, Zellmeier Evelyn, Benthaus Tobias, Sauerland Maria-Cristina, Berdel Wolfgang E, Büchner Thomas, Wörmann Bernhard, Braess Jan, Hiddemann Wolfgang, Bohlander Stefan K, Spiekermann Karsten

Abstract excerpt

PURPOSE: CEBPA mutations are found as either biallelic (biCEBPA) or monoallelic (moCEBPA). We set out to explore whether the kind of CEBPA mutation is of prognostic relevance in cytogenetically normal (CN) acute myeloid leukemia (AML). PATIENTS AND METHODS: Four hundred sixty-seven homogeneously...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20038735
DOI: 10.1200/JCO.2008.21.6010

Genes

FLT3
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20038735-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Acute myeloid leukemia with biallelic CEBPA gene mutations and normal karyotype represents a distinct genetic entity associated with a favorable clinical outcome.PMID 20038735Read ↗

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