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Article

Prognostic impact of FLT3-ITD, NPM1 mutation and CEBPA bZIP domain mutation in cytogenetically normal acute myeloid leukemia: a Hokkaido Leukemia Net study.

International journal of hematology - 1 Jul 2023

Miyashita Naoki, Onozawa Masahiro, Yoshida Shota, Kimura Hiroyuki, Takahashi Shogo, Yokoyama Shota, Matsukawa Toshihiro, Hirabayashi Shinsuke, Fujisawa Shinichi, Mori Akio, Ota Shuichi, Kakinoki Yasutaka, Tsutsumi Yutaka, Yamamoto Satoshi, Miyagishima Takuto, Nagashima Takahiro, Ibata Makoto, Wakasa Kentaro, Haseyama Yoshihito, Fujimoto Katsuya, Ishihara Toshimichi, Sakai Hajime, Kondo Takeshi, Teshima Takanori

Abstract excerpt

Mutation status of FLT3, NPM1, and CEBPA is used to classify the prognosis of acute myeloid leukemia, but its significance in patients with cytogenetically normal (CN) AML is unclear. We prospectively analyzed these genes in 295 patients with CN-AML and identified 76 (25.8%) FLT3-ITD, 113 (38.3%) NPM1 mutations, and 30 (10.2%) CEBPA biallelic mutations. We found that patients with FLT3-ITD had a poor prognosis at...

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PMID: 36853451
DOI: 10.1007/s12185-023-03567-1

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