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Article

Frequency and prognostic impact of CEBPA proximal, distal and core promoter methylation in normal karyotype AML: a study on 623 cases.

PloS one - 1 Jan 2013

Fasan Annette, Alpermann Tamara, Haferlach Claudia, Grossmann Vera, Roller Andreas, Kohlmann Alexander, Eder Christiane, Kern Wolfgang, Haferlach Torsten, Schnittger Susanne

Abstract excerpt

The clinical impact of aberrant CEBPA promoter methylation (PM) in AML is controversially discussed. The aim of this study was to clarify the significance of aberrant CEBPA PM with regard to clinical features in a cohort of 623 cytogenetically normal (CN) de novo AML. 555 cases had wild-type CEBPA, 68 cases harbored CEBPA mutations. The distal promoter was methylated in 238/623 cases (38.2%), the core promoter in...

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Share to CCAAT-Enhancer-Binding Proteins
Share to Core Binding Factor Alpha 2 Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23383300
DOI: 10.1371/journal.pone.0054365
PMCID: PMC3562230

Genes

FLT3
TET2
NPM1
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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