Article
Monoallelic CEBPA mutations in normal karyotype acute myeloid leukemia: independent favorable prognostic factor within NPM1 mutated patients.
Annals of hematology - 1 Jul 2012
Dufour Annika, Schneider Friederike, Hoster Eva, Benthaus Tobias, Ksienzyk Bianka, Schneider Stephanie, Kakadia Purvi M, Sauerland Maria-Cristina, Berdel Wolfgang E, Büchner Thomas, Wörmann Bernhard, Braess Jan, Subklewe Marion, Hiddemann Wolfgang, Bohlander Stefan K, Spiekermann Karsten
Abstract excerpt
We and others have shown that cytogenetically normal (CN)-AML patients with biallelic CEBPA gene mutations (biCEBPA) represent a molecularly distinct group with a favorable prognosis. Patients carrying a monoallelic CEBPA mutation (moCEBPA), however, show no different outcome compared to patients with wildtype CEBPA, and these mutations are frequently associated with mutated NPM1 or FLT3-ITD. So far, no molecular...
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