Article
A trimer of dimers is the basic building block for human immunodeficiency virus-1 capsid assembly.
Biochemistry - 5 Jun 2012
Tsiang Manuel, Niedziela-Majka Anita, Hung Magdeleine, Jin Debi, Hu Eric, Yant Stephen, Samuel Dharmaraj, Liu Xiaohong, Sakowicz Roman
Abstract excerpt
Human immunodeficiency virus-1 (HIV-1) capsid protein (CA) has become a target of antiviral drug design in recent years. The recognition that binding of small molecules to the CA protein can result in the perturbation of capsid assembly or disassembly has led to mathematical modeling of the process. Although a number of capsid assembly models have been developed using biophysical parameters of the CA protein...
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