Immature HIV-1 Lattice Assembly Dynamics are Regulated by Scaffolding from Nucleic Acid and the Plasma Membrane

Abstract excerpt

<h4>ABSTRACT</h4> The packaging and budding of Gag polyprotein and viral ribonucleic acid (RNA) is a critical step in the human immunodeficiency virus-1 (HIV-1) lifecycle. High-resolution structures of the Gag polyprotein have revealed that the capsid (CA) and spacer peptide 1 (SP1) domains contain important interfaces for Gag self-assembly. However, the molecular details of the multimerization process, especiall...

Topics

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• Capsid Proteins
• Cell-Free System
• gag Gene Products, Human Immunodeficiency Virus
• Gene Knockdown Techniques
• In Vitro Techniques
• Molecular Imaging
• Protein Interaction Domains and Motifs
• Virus Assembly

Identifiers and source

Literature Corpus work

312da408-ec40-5454-90e9-54ba5fea0cfb

DOI

10.1101/163295