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Article

X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability

5 Jun 2015

Abstract excerpt

The detailed molecular interactions between native HIV-1 capsid protein (CA) hexamers that shield the viral genome and proteins have been elusive. We report crystal structures describing interactions between CA monomers related by sixfold symmetry within hexamers (intrahexamer) and threefold and twofold symmetry between neighboring hexamers (interhexamer). The structures describe how CA builds hexagonal lattices,...

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PMID: 26044298
DOI: 10.1126/science.aaa5936

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