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Article

A126 in the active site and TI167/168 in the TI loop are essential determinants of the substrate specificity of PTEN.

Cellular and molecular life sciences : CMLS - 1 Nov 2018

Leitner Michael G, Hobiger Kirstin, Mavrantoni Angeliki, Feuer Anja, Oberwinkler Johannes, Oliver Dominik, Halaszovich Christian R

Abstract excerpt

PTEN prevents tumor genesis by antagonizing the PI3 kinase/Akt pathway through D3 site phosphatase activity toward PI(3,4)P2 and PI(3,4,5)P3. The structural determinants of this important specificity remain unknown. Interestingly, PTEN shares remarkable homology to voltage-sensitive phosphatases (VSPs) that dephosphorylate D5 and D3 sites of PI(4,5)P2, PI(3,4)P2, and PI(3,4,5)P3. Since the catalytic center of...

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Identifiers

PMID: 29987362
DOI: 10.1007/s00018-018-2867-z
PMCID: PMC6182344

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PTEN

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A126 in the active site and TI167/168 in the TI loop are essential determinants of the substrate specificity of PTEN.PMID 29987362Read ↗

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