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Article

Coupling of Ci-VSP modules requires a combination of structure and electrostatics within the linker.

Biophysical journal - 21 Mar 2012

Hobiger Kirstin, Utesch Tillmann, Mroginski Maria Andrea, Friedrich Thomas

Abstract excerpt

The voltage-sensitive phosphatase Ci-VSP consists of an intracellular phosphatase domain (PD) coupled to a transmembrane voltage-sensor domain (VSD). Depolarization triggers the selective dephosphorylation of phosphoinositides. However, the molecular mechanisms of coupling are still elusive. To clarify the role of the VSD-PD linker as a putative partner for electrostatic interactions with the membrane, we carried...

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Source

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Identifiers

PMID: 22455914
DOI: 10.1016/j.bpj.2012.02.027
PMCID: PMC3309284

Genes

KCNQ2
KCNQ3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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