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Article

The linker pivot in Ci-VSP: the key to unlock catalysis.

PloS one - 1 Jan 2013

Hobiger Kirstin, Utesch Tillmann, Mroginski Maria Andrea, Seebohm Guiscard, Friedrich Thomas

Abstract excerpt

In the voltage-sensitive phosphatase Ci-VSP, conformational changes in the transmembrane voltage sensor domain (VSD) are transduced to the intracellular catalytic domain (CD) leading to its dephosphorylation activity against membrane-embedded phosphoinositides. The linker between both domains is...

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Identifiers

PMID: 23922964
DOI: 10.1371/journal.pone.0070272
PMCID: PMC3726396

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23922964-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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