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Article

Rab8 and Rabin8-Mediated Tumor Formation by Hyperactivated EGFR Signaling via FGFR Signaling.

International journal of molecular sciences - 20 Oct 2020

Choi Junghwa, Sung Jee Young, Lee Saerom, Yoo Jungyoen, Rongo Christopher, Kim Yong-Nyun, Shim Jaegal

Abstract excerpt

The epidermal growth factor receptor (EGFR) signaling is important for normal development, such as vulval development in Caenorhabditis elegans, and hyperactivation of the EGFR is often associated with cancer development. Our previous report demonstrated the multivulva (Muv) phenotype, a tumor model in C. elegans (jgIs25 strain) by engineering LET-23/EGFR with a TKI-resistant human EGFR T790-L858 mutant. Because...

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PMID: 33092268
DOI: 10.3390/ijms21207770
PMCID: PMC7589727

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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