Article
LET-502/ROCK Regulates Endocytic Recycling by Promoting Activation of RAB-5 in a Distinct Subpopulation of Sorting Endosomes.
Cell reports - 22 Sept 2020
Zhang Wenjuan, Wang Shimin, Yang Chao, Hu Can, Chen Dan, Luo Qian, He Zhen, Liao Yuhan, Yao Yuxin, Chen Juan, He Jun, Hu Junbo, Xia Tian, Lin Long, Shi Anbing
Abstract excerpt
To explore the mechanism of Rab5/RAB-5 activation during endocytic recycling, we perform a genome-wide RNAi screen and identify a recycling regulator, LET-502/ROCK. LET-502 preferentially interacts with RAB-5(GDP) and activates RABX-5 GEF activity toward RAB-5, presumably by disrupting the self-inhibiting conformation of RABX-5. Furthermore, we find that the concomitant loss of LET-502 and another CED-10...
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