Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells.

Cell - 18 Sept 1998

Kaech S M, Whitfield C W, Kim S K

Abstract excerpt

In C. elegans, the LET-23 receptor tyrosine kinase is localized to the basolateral membranes of polarized vulval epithelial cells. lin-2, lin-7, and lin-10 are required for basolateral localization of LET-23, since LET-23 is mislocalized to the apical membrane in lin-2, lin-7, and lin-10 mutants. Yeast two-hybrid, in vitro binding, and in vivo coimmunoprecipitation experiments show that LIN-2, LIN-7, and LIN-10...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Drosophila
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Membrane Proteins

Share to Mutation

Share to Protein Binding

Share to Proteins

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 9753323
DOI: 10.1016/s0092-8674(00)81735-3
PMCID: PMC3224769

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells.PMID 9753323Read ↗

LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction.Semantic proximity Read ↗

Basolateral localization of the Caenorhabditis elegans epidermal growth factor receptor in epithelial cells by the PDZ protein LIN-10.Semantic proximity Read ↗

Mutations in the Caenorhabditis elegans let-23 EGFR-like gene define elements important for cell-type specificity and function.Semantic proximity Read ↗

Multiple functions of let-23, a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction.Semantic proximity Read ↗

An In Vivo EGF Receptor Localization Screen in C. elegans Identifies the Ezrin Homolog ERM-1 as a Temporal Regulator of SignalingSemantic proximity Read ↗

RAB-7 antagonizes LET-23 EGFR signaling during vulva development in Caenorhabditis elegans.Semantic proximity Read ↗

A point mutation in the extracellular domain activates LET-23, the Caenorhabditis elegans epidermal growth factor receptor homolog.Semantic proximity Read ↗

sli-3 negatively regulates the LET-23/epidermal growth factor receptor-mediated vulval induction pathway in Caenorhabditis elegans.Semantic proximity Read ↗

sli-1, a negative regulator of let-23-mediated signaling in C. elegans.Semantic proximity Read ↗

Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-23 receptor tyrosine kinase.Semantic proximity Read ↗

Interaction with mLin-7 alters the targeting of endocytosed transmembrane proteins in mammalian epithelial cells.Semantic proximity Read ↗

C. elegans AP-2 and retromer control Wnt signaling by regulating mig-14/Wntless.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.