Article
The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells.
Cell - 18 Sept 1998
Kaech S M, Whitfield C W, Kim S K
Abstract excerpt
In C. elegans, the LET-23 receptor tyrosine kinase is localized to the basolateral membranes of polarized vulval epithelial cells. lin-2, lin-7, and lin-10 are required for basolateral localization of LET-23, since LET-23 is mislocalized to the apical membrane in lin-2, lin-7, and lin-10 mutants....
Topics
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Drosophila
- Epithelial Cells
- ErbB Receptors
- Female
- Gene Expression Regulation, Enzymologic
- Helminth Proteins
- Mammals
- Membrane Proteins
- Multienzyme Complexes
- Mutation
- Precipitin Tests
- Protein Binding
- Protein Structure, Tertiary
- Proteins
- Signal Transduction